

		Proteomics is often simply associated with mass spectrometry only. But mass spectrometry is only a part of the highly complex method. The first step is an observation, for example: why does a biological system reacts on a stimulus as a drug or what changes a system from healthy to diseased state. Proteomics starts from asking the question to the biological system, planning the experiments, getting meaningful samples, applying the correct analysis and doing the data, bioinformatics, and statistical analysis to turn data into information. In the next step, taking the information obtained from the data, redefine the experiment and validate and verify the information. Furthermore, Proteomics does not stand alone, information from Genomic, Metabolomic, Lipidomic, to name only a few, have to be integrated for a meaningful explanation of the observation and to draw conclusions which will lead to treatments of diseases. To establish Proteomics' methods in a lab, we provide consultation and training, from planning experiments, hands-on in the workflow to data, bioinformatics, and statistical analysis.

5TH INTERNATIONAL SINGAPORE LIPID SYMPOSIUM 2014

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Proteins are the active component of a cell, an organ, a tissue, the whole body. They are encoded in the genome, the human genome contains the information for around 22,000 proteins, the tomato genome for more than 30,000. But this is not the final status, proteins get differentially processed, modified, expressed, undergo different interactions, making the biology more complex. From the 22,000 genes, at least 500,000 different proteins are made.

The statement "DNA makes RNA makes Proteins" is a much simplified picture. There is much more happening. Proteins control the expression of proteins, modify DNA and RNA.

Proteomics is the key technique to study proteins in a biological context. Proteomics' techniques enable the identification of new drug targets, of biomarkers for early disease diagnostics and understanding of biological processes.

And they make metabolites, small molecules which transfer information across the cells, they modify proteins, they make lipids and bind to them. To understand biological functions and to understand the development of a disease, all these have to be studied in detail. Genomics only gives a blueprint, Transcriptomics an idea about the proteins present, Proteomics about the working horses in the cell, Systems Biology or Integrated Biology will give the complete complex picture.

To study Integrated Biology many diifferent techniques and approaches have to be brought together.